Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study.
Identifieur interne : 001803 ( Main/Exploration ); précédent : 001802; suivant : 001804Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study.
Auteurs : Elena H. Martinez-Lapiscina [Espagne] ; Sam Arnow [États-Unis] ; James A. Wilson [États-Unis] ; Shiv Saidha [États-Unis] ; Jana Lizrova Preiningerova [République tchèque] ; Timm Oberwahrenbrock [Allemagne] ; Alexander U. Brandt [Allemagne] ; Luis E. Pablo [Espagne] ; Simone Guerrieri [Italie] ; Ines Gonzalez [Espagne] ; Olivier Outteryck [France] ; Ann-Kristin Mueller [Allemagne] ; Phillip Albrecht [Allemagne] ; Wesley Chan [Canada] ; Sebastian Lukas [Suisse] ; Lisanne J. Balk [Pays-Bas] ; Clare Fraser [Australie] ; Jette L. Frederiksen [Danemark] ; Jennifer Resto [États-Unis] ; Teresa Frohman [États-Unis] ; Christian Cordano [États-Unis] ; Irati Zubizarreta [Espagne] ; Magi Andorra [Espagne] ; Bernardo Sanchez-Dalmau [Espagne] ; Albert Saiz [Espagne] ; Robert Bermel [États-Unis] ; Alexander Klistorner [Australie] ; Axel Petzold [Royaume-Uni] ; Sven Schippling [Suisse] ; Fiona Costello [Canada] ; Orhan Aktas [Allemagne] ; Patrick Vermersch [France] ; Celia Oreja-Guevara [Espagne] ; Giancarlo Comi [Italie] ; Letizia Leocani [Italie] ; Elena Garcia-Martin [Espagne] ; Friedemann Paul [Allemagne] ; Eva Havrdova [République tchèque] ; Elliot Frohman [États-Unis] ; Laura J. Balcer [États-Unis] ; Ari J. Green [États-Unis] ; Peter A. Calabresi [États-Unis] ; Pablo Villoslada [États-Unis]Source :
- The Lancet. Neurology [ 1474-4465 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Femelle, Humains, Indice de gravité médicale, Macula (imagerie diagnostique), Mâle, Neurones rétiniens (anatomopathologie), Pronostic, Rétinopathies (imagerie diagnostique), Rétinopathies (étiologie), Sclérose en plaques (), Sclérose en plaques (physiopathologie), Tomographie par cohérence optique (), Études de cohortes, Études de suivi, Évolution de la maladie.
- MESH :
- anatomopathologie : Neurones rétiniens.
- imagerie diagnostique : Macula, Rétinopathies.
- physiopathologie : Sclérose en plaques.
- étiologie : Rétinopathies.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Indice de gravité médicale, Mâle, Pronostic, Sclérose en plaques, Tomographie par cohérence optique, Études de cohortes, Études de suivi, Évolution de la maladie.
English descriptors
- KwdEn :
- Adult, Cohort Studies, Disease Progression, Female, Follow-Up Studies, Humans, Macula Lutea (diagnostic imaging), Male, Middle Aged, Multiple Sclerosis (complications), Multiple Sclerosis (physiopathology), Prognosis, Retinal Diseases (diagnostic imaging), Retinal Diseases (etiology), Retinal Neurons (pathology), Severity of Illness Index, Tomography, Optical Coherence (methods).
- MESH :
- complications : Multiple Sclerosis.
- diagnostic imaging : Macula Lutea, Retinal Diseases.
- etiology : Retinal Diseases.
- methods : Tomography, Optical Coherence.
- pathology : Retinal Neurons.
- physiopathology : Multiple Sclerosis.
- Adult, Cohort Studies, Disease Progression, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prognosis, Severity of Illness Index.
Abstract
Most patients with multiple sclerosis without previous optic neuritis have thinner retinal layers than healthy controls. We assessed the role of peripapillary retinal nerve fibre layer (pRNFL) thickness and macular volume in eyes with no history of optic neuritis as a biomarker of disability worsening in a cohort of patients with multiple sclerosis who had at least one eye without optic neuritis available.
DOI: 10.1016/S1474-4422(16)00068-5
PubMed: 27011339
Affiliations:
- Allemagne, Australie, Canada, Danemark, Espagne, France, Italie, Pays-Bas, Royaume-Uni, République tchèque, Suisse, États-Unis
- Alberta, Angleterre, Berlin, Bohême centrale, Californie, Canton de Zurich, Catalogne, Communauté de Madrid, District de Düsseldorf, Grand Londres, Hauts-de-France, Hollande-Septentrionale, Lombardie, Maryland, Nord-Pas-de-Calais, Nouvelle-Galles du Sud, Ohio, Pennsylvanie, Rhénanie-du-Nord-Westphalie, Texas, État de New York
- Amsterdam, Barcelone, Berlin, Calgary, Düsseldorf, Lille, Londres, Madrid, Milan, Prague, Sydney, Zurich
- Université de Calgary, Université de Sydney, Université de Zurich
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Le document en format XML
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Balk</name><affiliation wicri:level="3"><nlm:affiliation>VU Medical Center, Amsterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>VU Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Fraser, Clare" sort="Fraser, Clare" uniqKey="Fraser C" first="Clare" last="Fraser">Clare Fraser</name><affiliation wicri:level="4"><nlm:affiliation>Save Sight Institute, University of Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Save Sight Institute, University of Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Frederiksen, Jette L" sort="Frederiksen, Jette L" uniqKey="Frederiksen J" first="Jette L" last="Frederiksen">Jette L. Frederiksen</name><affiliation wicri:level="1"><nlm:affiliation>Glostrup Hospital, University of Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Glostrup Hospital, University of Copenhagen</wicri:regionArea><wicri:noRegion>University of Copenhagen</wicri:noRegion></affiliation></author><author><name sortKey="Resto, Jennifer" sort="Resto, Jennifer" uniqKey="Resto J" first="Jennifer" last="Resto">Jennifer Resto</name><affiliation wicri:level="2"><nlm:affiliation>Cleveland Clinic Foundation, Cleveland, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cleveland Clinic Foundation, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Frohman, Teresa" sort="Frohman, Teresa" uniqKey="Frohman T" first="Teresa" last="Frohman">Teresa Frohman</name><affiliation wicri:level="2"><nlm:affiliation>University of Texas Southwestern Medical Center, Dallas, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Texas Southwestern Medical Center, Dallas, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Cordano, Christian" sort="Cordano, Christian" uniqKey="Cordano C" first="Christian" last="Cordano">Christian Cordano</name><affiliation wicri:level="2"><nlm:affiliation>University of California, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of California, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Zubizarreta, Irati" sort="Zubizarreta, Irati" uniqKey="Zubizarreta I" first="Irati" last="Zubizarreta">Irati Zubizarreta</name><affiliation wicri:level="3"><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Andorra, Magi" sort="Andorra, Magi" uniqKey="Andorra M" first="Magi" last="Andorra">Magi Andorra</name><affiliation wicri:level="3"><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Sanchez Dalmau, Bernardo" sort="Sanchez Dalmau, Bernardo" uniqKey="Sanchez Dalmau B" first="Bernardo" last="Sanchez-Dalmau">Bernardo Sanchez-Dalmau</name><affiliation wicri:level="3"><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Saiz, Albert" sort="Saiz, Albert" uniqKey="Saiz A" first="Albert" last="Saiz">Albert Saiz</name><affiliation wicri:level="3"><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Bermel, Robert" sort="Bermel, Robert" uniqKey="Bermel R" first="Robert" last="Bermel">Robert Bermel</name><affiliation wicri:level="2"><nlm:affiliation>Cleveland Clinic Foundation, Cleveland, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cleveland Clinic Foundation, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Klistorner, Alexander" sort="Klistorner, Alexander" uniqKey="Klistorner A" first="Alexander" last="Klistorner">Alexander Klistorner</name><affiliation wicri:level="4"><nlm:affiliation>Save Sight Institute, University of Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Save Sight Institute, University of Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Petzold, Axel" sort="Petzold, Axel" uniqKey="Petzold A" first="Axel" last="Petzold">Axel Petzold</name><affiliation wicri:level="3"><nlm:affiliation>VU Medical Center, Amsterdam, Netherlands; Moorfields Eye Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>VU Medical Center, Amsterdam, Netherlands; Moorfields Eye Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Schippling, Sven" sort="Schippling, Sven" uniqKey="Schippling S" first="Sven" last="Schippling">Sven Schippling</name><affiliation wicri:level="4"><nlm:affiliation>University of Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>University of Zurich, Zurich</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Costello, Fiona" sort="Costello, Fiona" uniqKey="Costello F" first="Fiona" last="Costello">Fiona Costello</name><affiliation wicri:level="4"><nlm:affiliation>University of Calgary, Calgary, AB, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Calgary, Calgary, AB</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author><author><name sortKey="Aktas, Orhan" sort="Aktas, Orhan" uniqKey="Aktas O" first="Orhan" last="Aktas">Orhan Aktas</name><affiliation wicri:level="3"><nlm:affiliation>University of Düsseldorf, Düsseldorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Düsseldorf, Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Vermersch, Patrick" sort="Vermersch, Patrick" uniqKey="Vermersch P" first="Patrick" last="Vermersch">Patrick Vermersch</name><affiliation wicri:level="3"><nlm:affiliation>University of Lille, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Oreja Guevara, Celia" sort="Oreja Guevara, Celia" uniqKey="Oreja Guevara C" first="Celia" last="Oreja-Guevara">Celia Oreja-Guevara</name><affiliation wicri:level="3"><nlm:affiliation>Hospital Clinico San Carlos, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Clinico San Carlos, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Comi, Giancarlo" sort="Comi, Giancarlo" uniqKey="Comi G" first="Giancarlo" last="Comi">Giancarlo Comi</name><affiliation wicri:level="3"><nlm:affiliation>San Raffaele Hospital, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>San Raffaele Hospital, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Leocani, Letizia" sort="Leocani, Letizia" uniqKey="Leocani L" first="Letizia" last="Leocani">Letizia Leocani</name><affiliation wicri:level="3"><nlm:affiliation>San Raffaele Hospital, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>San Raffaele Hospital, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Garcia Martin, Elena" sort="Garcia Martin, Elena" uniqKey="Garcia Martin E" first="Elena" last="Garcia-Martin">Elena Garcia-Martin</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Miguel Servet, Zaragoza, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Miguel Servet, Zaragoza</wicri:regionArea><wicri:noRegion>Zaragoza</wicri:noRegion></affiliation></author><author><name sortKey="Paul, Friedemann" sort="Paul, Friedemann" uniqKey="Paul F" first="Friedemann" last="Paul">Friedemann Paul</name><affiliation wicri:level="3"><nlm:affiliation>Experimental and Clinical Research Center and NeuroCure Clinical Research Center, Charité University Medicine and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Experimental and Clinical Research Center and NeuroCure Clinical Research Center, Charité University Medicine and Max Delbrueck Center for Molecular Medicine, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Havrdova, Eva" sort="Havrdova, Eva" uniqKey="Havrdova E" first="Eva" last="Havrdova">Eva Havrdova</name><affiliation wicri:level="3"><nlm:affiliation>Charles University, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Charles University, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Frohman, Elliot" sort="Frohman, Elliot" uniqKey="Frohman E" first="Elliot" last="Frohman">Elliot Frohman</name><affiliation wicri:level="2"><nlm:affiliation>University of Texas Southwestern Medical Center, Dallas, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Texas Southwestern Medical Center, Dallas, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Balcer, Laura J" sort="Balcer, Laura J" uniqKey="Balcer L" first="Laura J" last="Balcer">Laura J. Balcer</name><affiliation wicri:level="2"><nlm:affiliation>University of Pennsylvania, Philadelphia, PA, USA; New York University, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pennsylvania, Philadelphia, PA, USA; New York University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Green, Ari J" sort="Green, Ari J" uniqKey="Green A" first="Ari J" last="Green">Ari J. Green</name><affiliation wicri:level="2"><nlm:affiliation>University of California, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of California, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Calabresi, Peter A" sort="Calabresi, Peter A" uniqKey="Calabresi P" first="Peter A" last="Calabresi">Peter A. Calabresi</name><affiliation wicri:level="2"><nlm:affiliation>Johns Hopkins University, Baltimore, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins University, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Villoslada, Pablo" sort="Villoslada, Pablo" uniqKey="Villoslada P" first="Pablo" last="Villoslada">Pablo Villoslada</name><affiliation wicri:level="2"><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain; University of California, San Francisco, CA, USA. Electronic address: pvilloslada@clinic.ub.es.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain; University of California, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27011339</idno><idno type="pmid">27011339</idno><idno type="doi">10.1016/S1474-4422(16)00068-5</idno><idno type="wicri:Area/PubMed/Corpus">001F41</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001F41</idno><idno type="wicri:Area/PubMed/Curation">001F17</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001F17</idno><idno type="wicri:Area/PubMed/Checkpoint">001F17</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001F17</idno><idno type="wicri:Area/Ncbi/Merge">003323</idno><idno type="wicri:Area/Ncbi/Curation">003323</idno><idno type="wicri:Area/Ncbi/Checkpoint">003323</idno><idno type="wicri:Area/Main/Merge">001798</idno><idno type="wicri:Area/Main/Curation">001803</idno><idno type="wicri:Area/Main/Exploration">001803</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study.</title><author><name sortKey="Martinez Lapiscina, Elena H" sort="Martinez Lapiscina, Elena H" uniqKey="Martinez Lapiscina E" first="Elena H" last="Martinez-Lapiscina">Elena H. Martinez-Lapiscina</name><affiliation wicri:level="3"><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Arnow, Sam" sort="Arnow, Sam" uniqKey="Arnow S" first="Sam" last="Arnow">Sam Arnow</name><affiliation wicri:level="2"><nlm:affiliation>University of California, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of California, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Wilson, James A" sort="Wilson, James A" uniqKey="Wilson J" first="James A" last="Wilson">James A. Wilson</name><affiliation wicri:level="2"><nlm:affiliation>University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Saidha, Shiv" sort="Saidha, Shiv" uniqKey="Saidha S" first="Shiv" last="Saidha">Shiv Saidha</name><affiliation wicri:level="2"><nlm:affiliation>Johns Hopkins University, Baltimore, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins University, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Preiningerova, Jana Lizrova" sort="Preiningerova, Jana Lizrova" uniqKey="Preiningerova J" first="Jana Lizrova" last="Preiningerova">Jana Lizrova Preiningerova</name><affiliation wicri:level="3"><nlm:affiliation>Charles University, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Charles University, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Oberwahrenbrock, Timm" sort="Oberwahrenbrock, Timm" uniqKey="Oberwahrenbrock T" first="Timm" last="Oberwahrenbrock">Timm Oberwahrenbrock</name><affiliation wicri:level="3"><nlm:affiliation>Experimental and Clinical Research Center and NeuroCure Clinical Research Center, Charité University Medicine and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Experimental and Clinical Research Center and NeuroCure Clinical Research Center, Charité University Medicine and Max Delbrueck Center for Molecular Medicine, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Brandt, Alexander U" sort="Brandt, Alexander U" uniqKey="Brandt A" first="Alexander U" last="Brandt">Alexander U. Brandt</name><affiliation wicri:level="3"><nlm:affiliation>Experimental and Clinical Research Center and NeuroCure Clinical Research Center, Charité University Medicine and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Experimental and Clinical Research Center and NeuroCure Clinical Research Center, Charité University Medicine and Max Delbrueck Center for Molecular Medicine, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Pablo, Luis E" sort="Pablo, Luis E" uniqKey="Pablo L" first="Luis E" last="Pablo">Luis E. Pablo</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Miguel Servet, Zaragoza, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Miguel Servet, Zaragoza</wicri:regionArea><wicri:noRegion>Zaragoza</wicri:noRegion></affiliation></author><author><name sortKey="Guerrieri, Simone" sort="Guerrieri, Simone" uniqKey="Guerrieri S" first="Simone" last="Guerrieri">Simone Guerrieri</name><affiliation wicri:level="3"><nlm:affiliation>San Raffaele Hospital, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>San Raffaele Hospital, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Gonzalez, Ines" sort="Gonzalez, Ines" uniqKey="Gonzalez I" first="Ines" last="Gonzalez">Ines Gonzalez</name><affiliation wicri:level="3"><nlm:affiliation>Hospital Clinico San Carlos, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Clinico San Carlos, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Outteryck, Olivier" sort="Outteryck, Olivier" uniqKey="Outteryck O" first="Olivier" last="Outteryck">Olivier Outteryck</name><affiliation wicri:level="3"><nlm:affiliation>University of Lille, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Mueller, Ann Kristin" sort="Mueller, Ann Kristin" uniqKey="Mueller A" first="Ann-Kristin" last="Mueller">Ann-Kristin Mueller</name><affiliation wicri:level="3"><nlm:affiliation>University of Düsseldorf, Düsseldorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Düsseldorf, Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Albrecht, Phillip" sort="Albrecht, Phillip" uniqKey="Albrecht P" first="Phillip" last="Albrecht">Phillip Albrecht</name><affiliation wicri:level="3"><nlm:affiliation>University of Düsseldorf, Düsseldorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Düsseldorf, Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Chan, Wesley" sort="Chan, Wesley" uniqKey="Chan W" first="Wesley" last="Chan">Wesley Chan</name><affiliation wicri:level="4"><nlm:affiliation>University of Calgary, Calgary, AB, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Calgary, Calgary, AB</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author><author><name sortKey="Lukas, Sebastian" sort="Lukas, Sebastian" uniqKey="Lukas S" first="Sebastian" last="Lukas">Sebastian Lukas</name><affiliation wicri:level="4"><nlm:affiliation>University of Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>University of Zurich, Zurich</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Balk, Lisanne J" sort="Balk, Lisanne J" uniqKey="Balk L" first="Lisanne J" last="Balk">Lisanne J. Balk</name><affiliation wicri:level="3"><nlm:affiliation>VU Medical Center, Amsterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>VU Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Fraser, Clare" sort="Fraser, Clare" uniqKey="Fraser C" first="Clare" last="Fraser">Clare Fraser</name><affiliation wicri:level="4"><nlm:affiliation>Save Sight Institute, University of Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Save Sight Institute, University of Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Frederiksen, Jette L" sort="Frederiksen, Jette L" uniqKey="Frederiksen J" first="Jette L" last="Frederiksen">Jette L. Frederiksen</name><affiliation wicri:level="1"><nlm:affiliation>Glostrup Hospital, University of Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Glostrup Hospital, University of Copenhagen</wicri:regionArea><wicri:noRegion>University of Copenhagen</wicri:noRegion></affiliation></author><author><name sortKey="Resto, Jennifer" sort="Resto, Jennifer" uniqKey="Resto J" first="Jennifer" last="Resto">Jennifer Resto</name><affiliation wicri:level="2"><nlm:affiliation>Cleveland Clinic Foundation, Cleveland, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cleveland Clinic Foundation, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Frohman, Teresa" sort="Frohman, Teresa" uniqKey="Frohman T" first="Teresa" last="Frohman">Teresa Frohman</name><affiliation wicri:level="2"><nlm:affiliation>University of Texas Southwestern Medical Center, Dallas, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Texas Southwestern Medical Center, Dallas, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Cordano, Christian" sort="Cordano, Christian" uniqKey="Cordano C" first="Christian" last="Cordano">Christian Cordano</name><affiliation wicri:level="2"><nlm:affiliation>University of California, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of California, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Zubizarreta, Irati" sort="Zubizarreta, Irati" uniqKey="Zubizarreta I" first="Irati" last="Zubizarreta">Irati Zubizarreta</name><affiliation wicri:level="3"><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Andorra, Magi" sort="Andorra, Magi" uniqKey="Andorra M" first="Magi" last="Andorra">Magi Andorra</name><affiliation wicri:level="3"><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Sanchez Dalmau, Bernardo" sort="Sanchez Dalmau, Bernardo" uniqKey="Sanchez Dalmau B" first="Bernardo" last="Sanchez-Dalmau">Bernardo Sanchez-Dalmau</name><affiliation wicri:level="3"><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Saiz, Albert" sort="Saiz, Albert" uniqKey="Saiz A" first="Albert" last="Saiz">Albert Saiz</name><affiliation wicri:level="3"><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Bermel, Robert" sort="Bermel, Robert" uniqKey="Bermel R" first="Robert" last="Bermel">Robert Bermel</name><affiliation wicri:level="2"><nlm:affiliation>Cleveland Clinic Foundation, Cleveland, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cleveland Clinic Foundation, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Klistorner, Alexander" sort="Klistorner, Alexander" uniqKey="Klistorner A" first="Alexander" last="Klistorner">Alexander Klistorner</name><affiliation wicri:level="4"><nlm:affiliation>Save Sight Institute, University of Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Save Sight Institute, University of Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Petzold, Axel" sort="Petzold, Axel" uniqKey="Petzold A" first="Axel" last="Petzold">Axel Petzold</name><affiliation wicri:level="3"><nlm:affiliation>VU Medical Center, Amsterdam, Netherlands; Moorfields Eye Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>VU Medical Center, Amsterdam, Netherlands; Moorfields Eye Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Schippling, Sven" sort="Schippling, Sven" uniqKey="Schippling S" first="Sven" last="Schippling">Sven Schippling</name><affiliation wicri:level="4"><nlm:affiliation>University of Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>University of Zurich, Zurich</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Costello, Fiona" sort="Costello, Fiona" uniqKey="Costello F" first="Fiona" last="Costello">Fiona Costello</name><affiliation wicri:level="4"><nlm:affiliation>University of Calgary, Calgary, AB, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Calgary, Calgary, AB</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author><author><name sortKey="Aktas, Orhan" sort="Aktas, Orhan" uniqKey="Aktas O" first="Orhan" last="Aktas">Orhan Aktas</name><affiliation wicri:level="3"><nlm:affiliation>University of Düsseldorf, Düsseldorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Düsseldorf, Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Vermersch, Patrick" sort="Vermersch, Patrick" uniqKey="Vermersch P" first="Patrick" last="Vermersch">Patrick Vermersch</name><affiliation wicri:level="3"><nlm:affiliation>University of Lille, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Oreja Guevara, Celia" sort="Oreja Guevara, Celia" uniqKey="Oreja Guevara C" first="Celia" last="Oreja-Guevara">Celia Oreja-Guevara</name><affiliation wicri:level="3"><nlm:affiliation>Hospital Clinico San Carlos, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Clinico San Carlos, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Comi, Giancarlo" sort="Comi, Giancarlo" uniqKey="Comi G" first="Giancarlo" last="Comi">Giancarlo Comi</name><affiliation wicri:level="3"><nlm:affiliation>San Raffaele Hospital, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>San Raffaele Hospital, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Leocani, Letizia" sort="Leocani, Letizia" uniqKey="Leocani L" first="Letizia" last="Leocani">Letizia Leocani</name><affiliation wicri:level="3"><nlm:affiliation>San Raffaele Hospital, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>San Raffaele Hospital, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Garcia Martin, Elena" sort="Garcia Martin, Elena" uniqKey="Garcia Martin E" first="Elena" last="Garcia-Martin">Elena Garcia-Martin</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Miguel Servet, Zaragoza, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Miguel Servet, Zaragoza</wicri:regionArea><wicri:noRegion>Zaragoza</wicri:noRegion></affiliation></author><author><name sortKey="Paul, Friedemann" sort="Paul, Friedemann" uniqKey="Paul F" first="Friedemann" last="Paul">Friedemann Paul</name><affiliation wicri:level="3"><nlm:affiliation>Experimental and Clinical Research Center and NeuroCure Clinical Research Center, Charité University Medicine and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Experimental and Clinical Research Center and NeuroCure Clinical Research Center, Charité University Medicine and Max Delbrueck Center for Molecular Medicine, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Havrdova, Eva" sort="Havrdova, Eva" uniqKey="Havrdova E" first="Eva" last="Havrdova">Eva Havrdova</name><affiliation wicri:level="3"><nlm:affiliation>Charles University, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Charles University, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Frohman, Elliot" sort="Frohman, Elliot" uniqKey="Frohman E" first="Elliot" last="Frohman">Elliot Frohman</name><affiliation wicri:level="2"><nlm:affiliation>University of Texas Southwestern Medical Center, Dallas, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Texas Southwestern Medical Center, Dallas, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Balcer, Laura J" sort="Balcer, Laura J" uniqKey="Balcer L" first="Laura J" last="Balcer">Laura J. Balcer</name><affiliation wicri:level="2"><nlm:affiliation>University of Pennsylvania, Philadelphia, PA, USA; New York University, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pennsylvania, Philadelphia, PA, USA; New York University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Green, Ari J" sort="Green, Ari J" uniqKey="Green A" first="Ari J" last="Green">Ari J. Green</name><affiliation wicri:level="2"><nlm:affiliation>University of California, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of California, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Calabresi, Peter A" sort="Calabresi, Peter A" uniqKey="Calabresi P" first="Peter A" last="Calabresi">Peter A. Calabresi</name><affiliation wicri:level="2"><nlm:affiliation>Johns Hopkins University, Baltimore, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins University, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Villoslada, Pablo" sort="Villoslada, Pablo" uniqKey="Villoslada P" first="Pablo" last="Villoslada">Pablo Villoslada</name><affiliation wicri:level="2"><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain; University of California, San Francisco, CA, USA. Electronic address: pvilloslada@clinic.ub.es.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain; University of California, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">The Lancet. Neurology</title><idno type="eISSN">1474-4465</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Cohort Studies</term><term>Disease Progression</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Macula Lutea (diagnostic imaging)</term><term>Male</term><term>Middle Aged</term><term>Multiple Sclerosis (complications)</term><term>Multiple Sclerosis (physiopathology)</term><term>Prognosis</term><term>Retinal Diseases (diagnostic imaging)</term><term>Retinal Diseases (etiology)</term><term>Retinal Neurons (pathology)</term><term>Severity of Illness Index</term><term>Tomography, Optical Coherence (methods)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Indice de gravité médicale</term><term>Macula (imagerie diagnostique)</term><term>Mâle</term><term>Neurones rétiniens (anatomopathologie)</term><term>Pronostic</term><term>Rétinopathies (imagerie diagnostique)</term><term>Rétinopathies (étiologie)</term><term>Sclérose en plaques ()</term><term>Sclérose en plaques (physiopathologie)</term><term>Tomographie par cohérence optique ()</term><term>Études de cohortes</term><term>Études de suivi</term><term>Évolution de la maladie</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Neurones rétiniens</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Multiple Sclerosis</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Macula Lutea</term><term>Retinal Diseases</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Retinal Diseases</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Macula</term><term>Rétinopathies</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Tomography, Optical Coherence</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Retinal Neurons</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Sclérose en plaques</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Multiple Sclerosis</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Rétinopathies</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Cohort Studies</term><term>Disease Progression</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prognosis</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Indice de gravité médicale</term><term>Mâle</term><term>Pronostic</term><term>Sclérose en plaques</term><term>Tomographie par cohérence optique</term><term>Études de cohortes</term><term>Études de suivi</term><term>Évolution de la maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Most patients with multiple sclerosis without previous optic neuritis have thinner retinal layers than healthy controls. We assessed the role of peripapillary retinal nerve fibre layer (pRNFL) thickness and macular volume in eyes with no history of optic neuritis as a biomarker of disability worsening in a cohort of patients with multiple sclerosis who had at least one eye without optic neuritis available.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Danemark</li><li>Espagne</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>République tchèque</li><li>Suisse</li><li>États-Unis</li></country><region><li>Alberta</li><li>Angleterre</li><li>Berlin</li><li>Bohême centrale</li><li>Californie</li><li>Canton de Zurich</li><li>Catalogne</li><li>Communauté de Madrid</li><li>District de Düsseldorf</li><li>Grand Londres</li><li>Hauts-de-France</li><li>Hollande-Septentrionale</li><li>Lombardie</li><li>Maryland</li><li>Nord-Pas-de-Calais</li><li>Nouvelle-Galles du Sud</li><li>Ohio</li><li>Pennsylvanie</li><li>Rhénanie-du-Nord-Westphalie</li><li>Texas</li><li>État de New York</li></region><settlement><li>Amsterdam</li><li>Barcelone</li><li>Berlin</li><li>Calgary</li><li>Düsseldorf</li><li>Lille</li><li>Londres</li><li>Madrid</li><li>Milan</li><li>Prague</li><li>Sydney</li><li>Zurich</li></settlement><orgName><li>Université de Calgary</li><li>Université de Sydney</li><li>Université de Zurich</li></orgName></list><tree><country name="Espagne"><region name="Catalogne"><name sortKey="Martinez Lapiscina, Elena H" sort="Martinez Lapiscina, Elena H" uniqKey="Martinez Lapiscina E" first="Elena H" last="Martinez-Lapiscina">Elena H. Martinez-Lapiscina</name></region><name sortKey="Andorra, Magi" sort="Andorra, Magi" uniqKey="Andorra M" first="Magi" last="Andorra">Magi Andorra</name><name sortKey="Garcia Martin, Elena" sort="Garcia Martin, Elena" uniqKey="Garcia Martin E" first="Elena" last="Garcia-Martin">Elena Garcia-Martin</name><name sortKey="Gonzalez, Ines" sort="Gonzalez, Ines" uniqKey="Gonzalez I" first="Ines" last="Gonzalez">Ines Gonzalez</name><name sortKey="Oreja Guevara, Celia" sort="Oreja Guevara, Celia" uniqKey="Oreja Guevara C" first="Celia" last="Oreja-Guevara">Celia Oreja-Guevara</name><name sortKey="Pablo, Luis E" sort="Pablo, Luis E" uniqKey="Pablo L" first="Luis E" last="Pablo">Luis E. Pablo</name><name sortKey="Saiz, Albert" sort="Saiz, Albert" uniqKey="Saiz A" first="Albert" last="Saiz">Albert Saiz</name><name sortKey="Sanchez Dalmau, Bernardo" sort="Sanchez Dalmau, Bernardo" uniqKey="Sanchez Dalmau B" first="Bernardo" last="Sanchez-Dalmau">Bernardo Sanchez-Dalmau</name><name sortKey="Zubizarreta, Irati" sort="Zubizarreta, Irati" uniqKey="Zubizarreta I" first="Irati" last="Zubizarreta">Irati Zubizarreta</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Arnow, Sam" sort="Arnow, Sam" uniqKey="Arnow S" first="Sam" last="Arnow">Sam Arnow</name></region><name sortKey="Balcer, Laura J" sort="Balcer, Laura J" uniqKey="Balcer L" first="Laura J" last="Balcer">Laura J. Balcer</name><name sortKey="Bermel, Robert" sort="Bermel, Robert" uniqKey="Bermel R" first="Robert" last="Bermel">Robert Bermel</name><name sortKey="Calabresi, Peter A" sort="Calabresi, Peter A" uniqKey="Calabresi P" first="Peter A" last="Calabresi">Peter A. Calabresi</name><name sortKey="Cordano, Christian" sort="Cordano, Christian" uniqKey="Cordano C" first="Christian" last="Cordano">Christian Cordano</name><name sortKey="Frohman, Elliot" sort="Frohman, Elliot" uniqKey="Frohman E" first="Elliot" last="Frohman">Elliot Frohman</name><name sortKey="Frohman, Teresa" sort="Frohman, Teresa" uniqKey="Frohman T" first="Teresa" last="Frohman">Teresa Frohman</name><name sortKey="Green, Ari J" sort="Green, Ari J" uniqKey="Green A" first="Ari J" last="Green">Ari J. Green</name><name sortKey="Resto, Jennifer" sort="Resto, Jennifer" uniqKey="Resto J" first="Jennifer" last="Resto">Jennifer Resto</name><name sortKey="Saidha, Shiv" sort="Saidha, Shiv" uniqKey="Saidha S" first="Shiv" last="Saidha">Shiv Saidha</name><name sortKey="Villoslada, Pablo" sort="Villoslada, Pablo" uniqKey="Villoslada P" first="Pablo" last="Villoslada">Pablo Villoslada</name><name sortKey="Wilson, James A" sort="Wilson, James A" uniqKey="Wilson J" first="James A" last="Wilson">James A. Wilson</name></country><country name="République tchèque"><region name="Bohême centrale"><name sortKey="Preiningerova, Jana Lizrova" sort="Preiningerova, Jana Lizrova" uniqKey="Preiningerova J" first="Jana Lizrova" last="Preiningerova">Jana Lizrova Preiningerova</name></region><name sortKey="Havrdova, Eva" sort="Havrdova, Eva" uniqKey="Havrdova E" first="Eva" last="Havrdova">Eva Havrdova</name></country><country name="Allemagne"><region name="Berlin"><name sortKey="Oberwahrenbrock, Timm" sort="Oberwahrenbrock, Timm" uniqKey="Oberwahrenbrock T" first="Timm" last="Oberwahrenbrock">Timm Oberwahrenbrock</name></region><name sortKey="Aktas, Orhan" sort="Aktas, Orhan" uniqKey="Aktas O" first="Orhan" last="Aktas">Orhan Aktas</name><name sortKey="Albrecht, Phillip" sort="Albrecht, Phillip" uniqKey="Albrecht P" first="Phillip" last="Albrecht">Phillip Albrecht</name><name sortKey="Brandt, Alexander U" sort="Brandt, Alexander U" uniqKey="Brandt A" first="Alexander U" last="Brandt">Alexander U. Brandt</name><name sortKey="Mueller, Ann Kristin" sort="Mueller, Ann Kristin" uniqKey="Mueller A" first="Ann-Kristin" last="Mueller">Ann-Kristin Mueller</name><name sortKey="Paul, Friedemann" sort="Paul, Friedemann" uniqKey="Paul F" first="Friedemann" last="Paul">Friedemann Paul</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Guerrieri, Simone" sort="Guerrieri, Simone" uniqKey="Guerrieri S" first="Simone" last="Guerrieri">Simone Guerrieri</name></region><name sortKey="Comi, Giancarlo" sort="Comi, Giancarlo" uniqKey="Comi G" first="Giancarlo" last="Comi">Giancarlo Comi</name><name sortKey="Leocani, Letizia" sort="Leocani, Letizia" uniqKey="Leocani L" first="Letizia" last="Leocani">Letizia Leocani</name></country><country name="France"><region name="Hauts-de-France"><name sortKey="Outteryck, Olivier" sort="Outteryck, Olivier" uniqKey="Outteryck O" first="Olivier" last="Outteryck">Olivier Outteryck</name></region><name sortKey="Vermersch, Patrick" sort="Vermersch, Patrick" uniqKey="Vermersch P" first="Patrick" last="Vermersch">Patrick Vermersch</name></country><country name="Canada"><region name="Alberta"><name sortKey="Chan, Wesley" sort="Chan, Wesley" uniqKey="Chan W" first="Wesley" last="Chan">Wesley Chan</name></region><name sortKey="Costello, Fiona" sort="Costello, Fiona" uniqKey="Costello F" first="Fiona" last="Costello">Fiona Costello</name></country><country name="Suisse"><region name="Canton de Zurich"><name sortKey="Lukas, Sebastian" sort="Lukas, Sebastian" uniqKey="Lukas S" first="Sebastian" last="Lukas">Sebastian Lukas</name></region><name sortKey="Schippling, Sven" sort="Schippling, Sven" uniqKey="Schippling S" first="Sven" last="Schippling">Sven Schippling</name></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Balk, Lisanne J" sort="Balk, Lisanne J" uniqKey="Balk L" first="Lisanne J" last="Balk">Lisanne J. Balk</name></region></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Fraser, Clare" sort="Fraser, Clare" uniqKey="Fraser C" first="Clare" last="Fraser">Clare Fraser</name></region><name sortKey="Klistorner, Alexander" sort="Klistorner, Alexander" uniqKey="Klistorner A" first="Alexander" last="Klistorner">Alexander Klistorner</name></country><country name="Danemark"><noRegion><name sortKey="Frederiksen, Jette L" sort="Frederiksen, Jette L" uniqKey="Frederiksen J" first="Jette L" last="Frederiksen">Jette L. Frederiksen</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Petzold, Axel" sort="Petzold, Axel" uniqKey="Petzold A" first="Axel" last="Petzold">Axel Petzold</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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